Answer
The answer is Jo-Wilfried Tsonga and Stan Wawrinka. Along with Tomáš Berdych, these two players have each achieved victories over all four of the esteemed "Big Four" players–Roger Federer, Rafael Nadal, Novak Djokovic, and Andy Murray–in major tennis tournaments. Tsonga, Wawrinka, and Berdych form an exclusive group of players to have accomplished this feat in the highly competitive realm of men's tennis.