Answer
Serving from 1806 to 1807, Grenville's tenure as Prime Minister was relatively brief but consequential. During his time in office, he led the Ministry of All the Talents, a coalition government that sought to address pressing national concerns, including the ongoing Napoleonic Wars and domestic political unrest. Grenville's premiership was marked by his commitment to reform, evidenced by his efforts to abolish the slave trade and promote religious tolerance.